Definition: immune-mediated inflammation of blood vessels
Classifications: by size of the vessel, anatomical location, and immunological findings

Large Vessel Vasculities
  • Giant cell arteritis 
    • usually > 50 yo
    • inflammation of the temporal, vertebral, or ophthalamic arteries
    • increased ESR
    • histology = segmental
  • Takayasu arteritis
    • inflammation of the lg arteries branching from the aortic arch
    • downstream ischemia causing blindness
    • undetectable pulse in upper extremeties
Medium Vessel Vasculities
  • Polyarteritis nodosa
    • segmental nectrotizing inflammation of any vessel (most often kidney, heart, and liver)
    •  affects young adults
  • Kawasaki disease
    • acute vasculitis
    • primarily coronary vessels
  • Thromboangiitis obliterans
    • aka Buerger's disease
    • acute and chronic inflammation
    • inflammation that can spread to veins and nerves
Small Vessel Vasculities
  • Wegener granulomatosis
    • either acute or necrotizing
    • prominent lung involvement
  • Churg Strauss Syndrome
    • necrotizing granulomatous
    • affects vessels and surrounding tissues (usually heart and lungs)
    • numerous eosinophils
  • Microscopic polyangiitis
    • usually affects the skin
    • most caused by immune responses  

Photo source: http://www.wegenersgranulomatosis.net/5_autoimmune_vasculitis.php
Source: Hardcore: Pathology, Carter Wahl

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